With 29 percent of Americans taking five or more medications daily, and 119,000 deaths annually occurring from prescription medication-related issues, it is important to look at medication complexity — a little discussed topic. This infographic illustrates the issue and outlines community-based approaches to address it, such as developing risk algorithms to identify at-risk patients and simplifying medication use through comprehensive medication management. The infographic was produced through the Community Management of Medication Complexity Innovation Lab, an initiative led by the Center for Health Care Strategies with support from the Gordon and Betty Moore Foundation. See also the companion fact sheet, Understanding and Addressing Medication Complexity, and report, Opportunities to Enhance Community-Based Medication Management Strategies for People with Complex Health and Social Needs.